Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to better understand how people respond to
cancer-causing chemicals in cigarette smoke. Some people are able to get rid of these
chemicals as harmless agents while others suffer damage to their cells that can ultimately
result in cancer. We hope to develop a better understanding of how we can identify the people
who are in danger of getting cancer. Participants will complete questionnaires regarding
their health and smoking history. We will take blood samples to look at genes which determine
how the body breaks down some tobacco-related toxins. Participants will be given a small
amount of liquid to drink, containing alcohol, water, and a compound called deuterated
phenanthrene (DP), which is found in cigarette smoke and in the environment. Phenanthrene is
non-toxic and does not cause cancer, but this compound is broken down by the body in the same
way as cancer-causing agents. We will follow the pathway of this compound as it is broken
down in the body.
Phase:
Phase 1
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute